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prmt1 inhibitor furamidine  (MedChemExpress)


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    MedChemExpress prmt1 inhibitor furamidine
    Prmt1 Inhibitor Furamidine, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/prmt1 inhibitor furamidine/product/MedChemExpress
    Average 93 stars, based on 5 article reviews
    prmt1 inhibitor furamidine - by Bioz Stars, 2026-02
    93/100 stars

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    prmt1 inhibitor furamidine  (MedChemExpress)
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    MedChemExpress prmt1 inhibitor furamidine
    Prmt1 Inhibitor Furamidine, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    furamidine prmt1 inhibitor  (Tocris)
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    Tocris furamidine prmt1 inhibitor
    Effect of <t>furamidine</t> on proliferation of U87MG-derived GSCs in vitro and in vivo. ( A ) Protein expression levels of <t>PRMT1</t> in U87MG adherent and tumorsphere cells. Protein levels were detected by Western blotting and quantified by densitometry. β-Actin levels were used as a loading control. * p < 0.05. ( B ) Effect of furamidine on the proliferation and tumorsphere formation in U87MG-derived GSCs. Cells were treated with furamidine at various concentrations (0–100 μM) for 7 days. Cell proliferation was measured using the CellTiter-Glo ® luminescent assay system. Formed tumorspheres were counted under an optical microscope. ** p < 0.005, *** p < 0.001 vs. the control. ( C ) Effect of furamidine on tumor growth derived by U87MG GSCs in a CAM model. U87MG-derived GSCs were mixed with ECM gel in the absence or presence of the furamidine (10 µg/egg) and placed onto the CAM surface of fertilized chick eggs. After incubation for 7 days, the size and weight of the formed tumors were calculated. * p < 0.05 vs. the control.
    Furamidine Prmt1 Inhibitor, supplied by Tocris, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Effect of furamidine on proliferation of U87MG-derived GSCs in vitro and in vivo. ( A ) Protein expression levels of PRMT1 in U87MG adherent and tumorsphere cells. Protein levels were detected by Western blotting and quantified by densitometry. β-Actin levels were used as a loading control. * p < 0.05. ( B ) Effect of furamidine on the proliferation and tumorsphere formation in U87MG-derived GSCs. Cells were treated with furamidine at various concentrations (0–100 μM) for 7 days. Cell proliferation was measured using the CellTiter-Glo ® luminescent assay system. Formed tumorspheres were counted under an optical microscope. ** p < 0.005, *** p < 0.001 vs. the control. ( C ) Effect of furamidine on tumor growth derived by U87MG GSCs in a CAM model. U87MG-derived GSCs were mixed with ECM gel in the absence or presence of the furamidine (10 µg/egg) and placed onto the CAM surface of fertilized chick eggs. After incubation for 7 days, the size and weight of the formed tumors were calculated. * p < 0.05 vs. the control.

    Journal: International Journal of Molecular Sciences

    Article Title: Inhibition of PRMT1 Suppresses the Growth of U87MG-Derived Glioblastoma Stem Cells by Blocking the STAT3 Signaling Pathway

    doi: 10.3390/ijms25052950

    Figure Lengend Snippet: Effect of furamidine on proliferation of U87MG-derived GSCs in vitro and in vivo. ( A ) Protein expression levels of PRMT1 in U87MG adherent and tumorsphere cells. Protein levels were detected by Western blotting and quantified by densitometry. β-Actin levels were used as a loading control. * p < 0.05. ( B ) Effect of furamidine on the proliferation and tumorsphere formation in U87MG-derived GSCs. Cells were treated with furamidine at various concentrations (0–100 μM) for 7 days. Cell proliferation was measured using the CellTiter-Glo ® luminescent assay system. Formed tumorspheres were counted under an optical microscope. ** p < 0.005, *** p < 0.001 vs. the control. ( C ) Effect of furamidine on tumor growth derived by U87MG GSCs in a CAM model. U87MG-derived GSCs were mixed with ECM gel in the absence or presence of the furamidine (10 µg/egg) and placed onto the CAM surface of fertilized chick eggs. After incubation for 7 days, the size and weight of the formed tumors were calculated. * p < 0.05 vs. the control.

    Article Snippet: Furamidine (PRMT1 inhibitor), berbamine (CaMKIIγ inhibitor), and colivelin (STAT3 activator) were purchased from Tocris (Bristol, UK), Sigma-Aldrich (St. Louis, MO, USA), and MedChemExpress (Monmouth Junction, NJ, USA), respectively.

    Techniques: Derivative Assay, In Vitro, In Vivo, Expressing, Western Blot, Control, Luminescence Assay, Microscopy, Incubation

    Effect of furamidine on cell cycle and apoptosis in U87MG-derived GSCs. ( A – D ) U87MG-derived GSCs were treated with furamidine (10, 20, and 40 μM) for 48 h. ( A ) Cells were stained with Muse ® Cell Cycle reagent, and cell cycle distribution was measured using the Muse Cell Analyzer. ( B ) Cells were stained with Muse ® Annexin V and Dead Cell reagent, and apoptotic cells were detected using the Muse Cell Analyzer. ( C , D ) The expression levels of cell cycle and apoptosis-related proteins were detected by Western blotting and quantified by densitometry. β-Actin levels were used as a loading control. * p < 0.05 vs. the control.

    Journal: International Journal of Molecular Sciences

    Article Title: Inhibition of PRMT1 Suppresses the Growth of U87MG-Derived Glioblastoma Stem Cells by Blocking the STAT3 Signaling Pathway

    doi: 10.3390/ijms25052950

    Figure Lengend Snippet: Effect of furamidine on cell cycle and apoptosis in U87MG-derived GSCs. ( A – D ) U87MG-derived GSCs were treated with furamidine (10, 20, and 40 μM) for 48 h. ( A ) Cells were stained with Muse ® Cell Cycle reagent, and cell cycle distribution was measured using the Muse Cell Analyzer. ( B ) Cells were stained with Muse ® Annexin V and Dead Cell reagent, and apoptotic cells were detected using the Muse Cell Analyzer. ( C , D ) The expression levels of cell cycle and apoptosis-related proteins were detected by Western blotting and quantified by densitometry. β-Actin levels were used as a loading control. * p < 0.05 vs. the control.

    Article Snippet: Furamidine (PRMT1 inhibitor), berbamine (CaMKIIγ inhibitor), and colivelin (STAT3 activator) were purchased from Tocris (Bristol, UK), Sigma-Aldrich (St. Louis, MO, USA), and MedChemExpress (Monmouth Junction, NJ, USA), respectively.

    Techniques: Derivative Assay, Staining, Expressing, Western Blot, Control

    Effect of furamidine on features of mitochondria-mediated apoptosis in U87MG-derived GSCs. ( A – C ) U87MG-derived GSCs were treated with furamidine (10, 20, and 40 μM) for 48 h. ( A ) Changes in nuclear morphology were observed by DAPI staining under a fluorescence microscope. Condensed and fragmented nuclei were indicated by white arrows. ( B ) MMP was detected by TMRE staining. Fluorescent images were quantified with densitometry. ( C ) Intracellular ROS levels were detected by DCFH-DA staining. DCF fluorescence was quantified by densitometry. * p < 0.05, *** p < 0.001 vs. the control.

    Journal: International Journal of Molecular Sciences

    Article Title: Inhibition of PRMT1 Suppresses the Growth of U87MG-Derived Glioblastoma Stem Cells by Blocking the STAT3 Signaling Pathway

    doi: 10.3390/ijms25052950

    Figure Lengend Snippet: Effect of furamidine on features of mitochondria-mediated apoptosis in U87MG-derived GSCs. ( A – C ) U87MG-derived GSCs were treated with furamidine (10, 20, and 40 μM) for 48 h. ( A ) Changes in nuclear morphology were observed by DAPI staining under a fluorescence microscope. Condensed and fragmented nuclei were indicated by white arrows. ( B ) MMP was detected by TMRE staining. Fluorescent images were quantified with densitometry. ( C ) Intracellular ROS levels were detected by DCFH-DA staining. DCF fluorescence was quantified by densitometry. * p < 0.05, *** p < 0.001 vs. the control.

    Article Snippet: Furamidine (PRMT1 inhibitor), berbamine (CaMKIIγ inhibitor), and colivelin (STAT3 activator) were purchased from Tocris (Bristol, UK), Sigma-Aldrich (St. Louis, MO, USA), and MedChemExpress (Monmouth Junction, NJ, USA), respectively.

    Techniques: Derivative Assay, Staining, Fluorescence, Microscopy, Control

    Effect of furamidine on STAT3 and stemness markers in U87MG-derived GSCs. ( A ) U87MG-derived GSCs were treated with furamidine (10, 20, and 40 μM) for 48 h. Protein levels were detected by Western blotting and quantified by densitometry. β-Actin levels were used as a loading control. * p < 0.05 vs. the control. ( B ) Effect of colivelin on the antiproliferative activity of furamidine in U87MG-derived GSCs. Cells were incubated for 7 days after treatment with colivelin and furamidine. The CellTiter-Glo ® luminescent assay was performed to measure cell proliferation. * p < 0.05, ** p < 0.005.

    Journal: International Journal of Molecular Sciences

    Article Title: Inhibition of PRMT1 Suppresses the Growth of U87MG-Derived Glioblastoma Stem Cells by Blocking the STAT3 Signaling Pathway

    doi: 10.3390/ijms25052950

    Figure Lengend Snippet: Effect of furamidine on STAT3 and stemness markers in U87MG-derived GSCs. ( A ) U87MG-derived GSCs were treated with furamidine (10, 20, and 40 μM) for 48 h. Protein levels were detected by Western blotting and quantified by densitometry. β-Actin levels were used as a loading control. * p < 0.05 vs. the control. ( B ) Effect of colivelin on the antiproliferative activity of furamidine in U87MG-derived GSCs. Cells were incubated for 7 days after treatment with colivelin and furamidine. The CellTiter-Glo ® luminescent assay was performed to measure cell proliferation. * p < 0.05, ** p < 0.005.

    Article Snippet: Furamidine (PRMT1 inhibitor), berbamine (CaMKIIγ inhibitor), and colivelin (STAT3 activator) were purchased from Tocris (Bristol, UK), Sigma-Aldrich (St. Louis, MO, USA), and MedChemExpress (Monmouth Junction, NJ, USA), respectively.

    Techniques: Derivative Assay, Western Blot, Control, Activity Assay, Incubation, Luminescence Assay

    Effect of combined treatment of furamidine and berbamine on proliferation of U87MG-derived GSCs. ( A ) Effect of combined treatment with furamidine and berbamine for 7 days on the proliferation and tumorsphere formation in U87MG-derived GSCs. ( B , C ) Effect of combined treatment with furamidine and berbamine for 48 h on ( B ) the cell cycle and ( C ) apoptotic cell death in U87MG-derived GSCs. * p < 0.05, *** p < 0.001 vs. the compound alone.

    Journal: International Journal of Molecular Sciences

    Article Title: Inhibition of PRMT1 Suppresses the Growth of U87MG-Derived Glioblastoma Stem Cells by Blocking the STAT3 Signaling Pathway

    doi: 10.3390/ijms25052950

    Figure Lengend Snippet: Effect of combined treatment of furamidine and berbamine on proliferation of U87MG-derived GSCs. ( A ) Effect of combined treatment with furamidine and berbamine for 7 days on the proliferation and tumorsphere formation in U87MG-derived GSCs. ( B , C ) Effect of combined treatment with furamidine and berbamine for 48 h on ( B ) the cell cycle and ( C ) apoptotic cell death in U87MG-derived GSCs. * p < 0.05, *** p < 0.001 vs. the compound alone.

    Article Snippet: Furamidine (PRMT1 inhibitor), berbamine (CaMKIIγ inhibitor), and colivelin (STAT3 activator) were purchased from Tocris (Bristol, UK), Sigma-Aldrich (St. Louis, MO, USA), and MedChemExpress (Monmouth Junction, NJ, USA), respectively.

    Techniques: Derivative Assay

    Effect of combined treatment of furamidine and berbamine on ( A ) PRMT1, CaMKIIγ, STAT3, and ( B ) stemness markers in U87MG-derived GSCs. ( A , B ) U87MG-derived GSCs were treated with the indicated concentrations of furamidine and berbamine for 48 h. Protein levels were detected by Western blotting and quantified by densitometry. β-Actin levels were used as a loading control. * p < 0.05 vs. the compound alone.

    Journal: International Journal of Molecular Sciences

    Article Title: Inhibition of PRMT1 Suppresses the Growth of U87MG-Derived Glioblastoma Stem Cells by Blocking the STAT3 Signaling Pathway

    doi: 10.3390/ijms25052950

    Figure Lengend Snippet: Effect of combined treatment of furamidine and berbamine on ( A ) PRMT1, CaMKIIγ, STAT3, and ( B ) stemness markers in U87MG-derived GSCs. ( A , B ) U87MG-derived GSCs were treated with the indicated concentrations of furamidine and berbamine for 48 h. Protein levels were detected by Western blotting and quantified by densitometry. β-Actin levels were used as a loading control. * p < 0.05 vs. the compound alone.

    Article Snippet: Furamidine (PRMT1 inhibitor), berbamine (CaMKIIγ inhibitor), and colivelin (STAT3 activator) were purchased from Tocris (Bristol, UK), Sigma-Aldrich (St. Louis, MO, USA), and MedChemExpress (Monmouth Junction, NJ, USA), respectively.

    Techniques: Derivative Assay, Western Blot, Control